Concanavalin A inhibits tissue factor coagulant activity.

Coagulant activity of leukocytes. Tissue factor activity.

Peritoneal leukocytes harvested from rabbits which have received two spaced doses of endotoxin have significantly greater (10-fold) coagulant activity than leukocytes from control rabbits. The coagulant activity accelerates the clotting of normal plasma and activates factor X in the presence of factor VII and calcium and is therefore regarded as tissue factor. A total of 40-80 mg tissue factor ...

Concanavalin A inhibition of tissue factor (thromboplastin) activity.

Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts.

The tissue-factor (thromboplastic) activity of cultured human endothelial cells and fibroblasts is low at time of transfer into fresh medium but increases 3-10 fold. Endothelial cells reach peak activity (400 U/10(5) cells) 5-8 hr after subculture. Activity in fibroblast cultures peaks (3000-12,000 U/10(5) cells) 7-12 hr after subculture. After attaining maximum activity, endothelial and fibrob...

Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor.

previous PV diagnosis, achieved at least CCyR. In summary, in this larger cohort of CML patients compared with that studied by Makishima et al,1 we found 2.55% of cases presenting concomitant BCR/ABL rearrangement and JAK2V617F mutation, indicating that the simultaneous occurrence of these mutations is rare event but it is not a phoenix; however, while the pathophysiologic significance of this ...

Murine tissue factor coagulant activity is critically dependent on the presence of an intact allosteric disulfide.

Tissue factor activation (decryption) has been proposed to be dependent on the cysteine 186-cysteine 209 allosteric disulfide in the tissue factor extracellular domain. Tissue factor procoagulant activity is under the control of protein disulfide isomerase-dependent modulation and nitrosylation of this disulfide. Human tissue factor disulfide mutants have been proposed as a model for encrypted ...